He began his musical journey with piano lessons at the age of 4. By the time he was 11 years old, he had focused his musical talents on the saxophone, playing numerous times with the marching band of his town. By age 20, he had played jazz throughout Europe, including Rome, Paris, Amsterdam, and Brussels. At that age, he also completed the seven-year Conservatory of Frosinone (Italy) program and landed a scholarship from Berklee College of Music in Boston. At his conservatory graduation, he performed the musically challenging Sequenza IXb by Luciano Berio, a virtuosic 20th-century masterpiece, as he prepared to cross an ocean.
 
In the spring of 2014, 5 months into his Performance Degree at Berklee, he was accepted into the Berklee Global Jazz Institute. This was a time of enriching and seemingly unbelievable experiences for Germani, seeing as he was now being taught directly by maestros he had long admired, including Dave Santoro, Danilo Perez, Dave Liebman, George Garzone, Joe Lovano, Ben Street, Jim Odgren, John Patitucci, Terri Lyne Carrington, Alan Pasqua among many others. Simultaneously, he was playing with contemporary musicians from all over the world and held performances consistently. Every Tuesday (with his quartet) and every Friday (with Cosimo Boni Quintet) of his four years at Berklee, he would play for the crowd at Wally's Jazz Club. He still praises the musical, personal, and professional growth from those performances and those years. After his bachelor's in May 2017, there was only one place where he wished to expand his growth even more: New York City.
 
Upon arriving in New York, where he currently resides, he quickly established himself as an on-demand sideman and bandleader and is actively involved in numerous musical projects. Today, he has traveled and performed in famous jazz festivals and clubs around the United States, South America, and Europe, such as Panama Jazz Festival with Dave Douglas Octet and the BGJI ambassadors, Umbria Jazz Festival in Perugia, Peperoncino Jazz Festival, Buenos Aires Jazz Festival, Cordoba Jazz Festival, Rosario Jazz Festival, Summer Time Casa del Jazz with David Kikoski Quartet, and George Garzone and Leo Genovese quintet. Since arriving in the United States, he has collaborated with many great musicians, such as Leo Genovese, Dave Douglas, Enrico Rava, Kenny Werner, Bob Moses, Dave Kikoski, George Garzone, Emanuele Basentini, and many others. Daniele was also among the last students to be taught by jazz legend Lee Konitz before passing in April 2020.
 
Daniele Germani has always believed that music is a powerful tool to develop people's creative and expressive potential and that it will always be a driving force in society, breaking down human barriers and uniting people. For him, this has been undoubtedly true.
Being a bandleader and having working groups on his name for over ten years has allowed Daniele to grow as a composer and arranger. In 2019, he challenged himself to compose one tune per day. Today, he has written over 650 tunes and released five records in his name. In 2023, Daniele founded Lyonhill Records in Brooklyn, NY.